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In the study, 3 percent of the people with positive FIT results were diagnosed with colorectal cancer (2,191 total cases). The study should also evaluate the location and detection rate of advanced adenomas and quantitative fecal hemoglobin results during the rounds of testing. K, Grossman Berger The use of FIT in symptomatic patients is associated with a better prognosis in CRC. H, Bishehsari Both studies appear in the Clinical Gastroenterology and Hepatology journal. Colorectal cancer screening comparing no screening, immunochemical and guaiac fecal occult blood tests: a cost-effectiveness analysis. Results were at least as good as from previous systematic reviews focusing n average-risk individuals.10,11,38 To ensure internal validity of our conclusions, we implemented current guidelines for the conduct and reporting of systematic reviews12,39 and used a prespecified protocol. de Wijkerslooth Z, Rozen The new study, published in Alimentary Pharmacology & Therapeutics, concluded that a positive test of ten micrograms or more of haemoglobin per gram of sample detects 91% of underlying cancers. Quiz Ref IDThe type of FIT used and cutoff threshold were the most important contributors to the heterogeneity of results. But there is a small chance (about 3 out of 100) that colonoscopy misses cancer or a polyp that could later turn into cancer . In a pragmatic trial34 assessing the effectiveness of a diagnostic strategy using annual FIT for 3 years for detection of AN vs colonoscopy in asymptomatic patients with a family history of CRC, annual FIT was as good as colonoscopy for AN; however, it missed almost 40% of advanced adenomas. Schnemann H, Brozek J, Guyatt G, Oxman A, ed; GRADE Working Group. Testing for fecal occult blood is commonly used as a cancer screen for colon cancer. FIT testing is recommended annually, and Cologuard every three years if testing is negative, but positive test results require a follow-up with colonoscopy. Researchers study the risk of false positives in colon cancer screening Our search identified 3026 records (Figure 1). C, Zubiaurre The first stool tests developed were based on the finding of occult, or hidden, blood. ST, Oort However, those who did not get a follow-up colonoscopy were about twice as likely to die of colorectal cancer over a 10-year period as those who did have a follow-up colonoscopy.