22 Rivkin et al 40 measured T2* values in brain tissue . -, Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, Launer LJ, Van Buchem MA, Breteler MM. Lewis P. Rowland, Timothy A. Pedley. Nakata Y, Shiga K, Yoshikawa K, Mizuno T, Mori S, Yamada K, Nakajima K: Subclinical brain hemorrhages in Alzheimers disease: evaluation by magnetic resonance T2*-weighted images. Qiu C, Cotch MF, Sigurdsson S, Jonsson PV, Jonsdottir MK, Sveinbjrnsdottir S, Eiriksdottir G, Klein R, Harris TB, van Buchem MA, Gudnason V, Launer LJ: Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study. Since lobar MBs in the context of AD are interpreted as markers of advanced CAA, lobar MB carriers (especially those with multiple MBs) are currently excluded from immunization trials as a safety measure [63]. Cerebral MBs are focal deposits of hemosiderin that indicate prior microhemorrhages around small vessels, related to either ruptured atherosclerotic microvessels or amyloid angiopathy. Kumar N. Neuroimaging in Superficial Siderosis: An In-Depth Look. Kikuta K, Takagi Y, Nozaki K, Okada T, Hashimoto N: Histological analysis of microbleed after surgical resection in a patient with moyamoya disease. There still exists another line of investigation providing support to the link between lobar MB and CAA, and it consists of the study of CAA patients with both MRI and Pittsburgh compound B (PiB)-positron emission tomography (PET) imaging. The .gov means its official. Cianchetti FA, Kim DH, Dimiduk S, Nishimura N, Schaffer CB: Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage. Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome. Cerebral microbleeds (MBs) are small chronic brain hemorrhages, likely caused by structural abnormalities of the small vessels. Kirsch W, McAuley G, Holshouser B, Petersen F, Ayaz M, Vinters HV, Dickson C, Haacke EM, Britt W, Larseng J, Kim I, Mueller C, Schrag M, Kido D: Serial susceptibility weighted MRI measures brain iron and microbleeds in dementia.
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