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They now are considered a sign of small blood vessel . White matter lesions are much more common in older or elderly people. To do this, WMH volume was regressed on adult IQ, adjusting for childhood IQ. Incidental white matter hyperintensities are common in brains of healthy individuals in their 60s and may be seen as early as the 30s and 40s. Hum Brain Mapp. Sometimes, white matter disease, particularly when it is severe, caninterfere with the way the brain works and the processes that it controls, including thinking and walking. Participants were members of the Dunedin Multidisciplinary Health and Development Study, a longitudinal investigation of health and behaviour in a population representative birth cohort. White Spots on a Brain MRI: What It Means - Healthgrades sharing sensitive information, make sure youre on a federal This protects the nerve fibres and gives white matter its colour. We used measurements from 23 of the 32 subjects for age-matched statistical . WMHs were common in the cohort, with an average volume of 953.50 mm3 (25th75th quartile = 425.251,142.44 mm3, median = 681.75; Fig. Thus, white matter hyperintensities may be a useful surrogate biomarker for identifying individuals in midlife at risk for future accelerated cognitive decline and selecting participants for dementia prevention trials. , Markus HS. Epub 2008 Sep 23. After receiving a brain scan result showing white matter lesions, youll likely have lots of questions. WMHs, also known as leukoaraiosis, are frequently identified in CT or MRI scans of elderly people.