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If the CSF protein concentration is >200 mg/dL, even high immunoglobulin production in the central nervous system can be obscured by the presence of plasma proteins. Tests that show an elevated level of OCBs indicate that a person might be living with MS. The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one of the diagnostic criteria for MS in the 2017 revised McDonald criteria. The presence of oligoclonal bands in CSF from patients with multiple sclerosis does not correlate with the activity of the demyelinating process. The results of the CSF oligoclonal banding test can indicate the presence of OCBs or elevated levels of OCB. The Consortium of Multiple Sclerosis Centers has endorsed IEF because of its increased sensitivity (>95%). Interpretation. However, most patients with a monoclonal protein will be finally diagnosed with MGUS rather than any of the malignant plasma cell dyscrasias for which treatment is recommended. Shah D, Seiter K. Multiple myeloma. Heavy/light chain specific immunoglobulin ratios provides no additional information than serum proteins electrophoresis and immunofixation for the diagnosis and the follow-up of intact immunoglobulin multiple myeloma patients. Given the dismal impact on prognosis in the latter scenario, Haematologica. PMC An EEG is a test that measures your brain waves and helps detect abnormal brain activity. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. 2019 Jan. [QxMD MEDLINE Link]. Bethesda, MD 20894, Web Policies and transmitted securely. Wallach, J. If the CSF protein concentration is >200 mg/dL, even high immunoglobulin production in the central nervous system can be obscured by the presence of plasma proteins. Immunofixation in CSF for the detection of oligoclonal bands is indicated every time there is suspicion for multiple sclerosis. 2018 Jun 27;56(7):1071-1080, 5. Cawley LP, Minard BJ, Tourtellotte WW, et al. Cerebrospinal fluid kappa and lambda free light chains in oligoclonal band-negative patients with suspected multiple sclerosis. The purpose of this test is to determine whether or not there are immunoglobulin proteins called oligoclonal bands dwelling in your cerebrospinal fluid.